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CS-W001157 4
Total: USD 88.00

4-Aminopyrimidin-5-ol

  • CAS No. 52601-89-5

  • Cat. No. CS-0157800
  • Purity≥98%
  • MDL No.MFCD18642504

*For research and further manufacturing use only, not for direct human use.

4-Aminopyrimidin-5-ol|CS-0157800

Structure of 52601-89-5

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General Information

  • CAS No. 52601-89-5
  • Cat. No. CS-0157800
  • Purity ≥98%
  • MDL No. MFCD18642504
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅N₃O
  • Molecular Weight None
  • Synonym(s) 5-Pyrimidinol, 4-amino- (7CI,9CI)
  • SMILES OC1=CN=CN=C1N

Description

4-Aminopyrimidin-5-ol features a fused heterocyclic scaffold with complementary amine and hydroxyl groups, enabling robust hydrogen bonding and enhanced solubility. This bench-stable compound integrates readily into medicinal chemistry campaigns, serving as a key pharmacophore in kinase inhibitors and antiviral agents.

Application

4-Aminopyrimidin-5-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and antiviral agents. Its dual functionality—amine and hydroxyl groups—supports diverse derivatization via coupling, alkylation, and cyclization reactions. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for scalable synthesis and high-throughput screening workflows.

Synthesis

  • Route1

    References

    • Myllymaeki, Mikko J.; Kaesnaenen, Heikki; Kataja, Antti O.; Lahtela-Kakkonen, Maija; Saario, Susanna M.; Poso, Antti; Koskinen, Ari M.P. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4179 - 4191

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.03
  • LogP   -0.2356
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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