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CS-W001157 4
Total: USD 88.00

4-Amino-6-chloropyrimidin-5-ol

  • CAS No. 38953-42-3

  • Cat. No. CS-0045900
  • Purity≥95%
  • MDL No.MFCD13689013

*For research and further manufacturing use only, not for direct human use.

4-Amino-6-chloropyrimidin-5-ol|CS-0045900

Structure of 38953-42-3

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General Information

  • CAS No. 38953-42-3
  • Cat. No. CS-0045900
  • Purity ≥95%
  • MDL No. MFCD13689013
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClN₃O
  • Molecular Weight 145.55
  • Synonym(s) 5-Pyrimidinol, 4-amino-6-chloro- (9CI)
  • SMILES OC1=C(Cl)N=CN=C1N

Description

4-Amino-6-chloropyrimidin-5-ol features a pyrimidine core with complementary amino and chloro substituents, enabling selective coupling in heterocyclic synthesis. This bench-stable scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor and antiviral agent development.

Application

4-Amino-6-chloropyrimidin-5-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based pharmacophores. Its amino and chloro groups offer orthogonal reactivity for nucleophilic substitution, Suzuki-Miyaura coupling, and amide formation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.03
  • LogP   0.4178
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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