4,6-Dichloro-5-methoxypyrimidine

Name: 4,6-Dichloro-5-methoxypyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5018-38-2
Cat. No. CS-W017299
Purity≥98%
MDL No.MFCD00087680

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4,6-Dichloro-5-methoxypyrimidine|CS-W017299

Structure of 5018-38-2

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General Information

CAS No. 5018-38-2
Cat. No. CS-W017299
Purity ≥98%
MDL No. MFCD00087680
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄Cl₂N₂O
Molecular Weight 179.00
Synonym(s) Pyrimidine, 4,6-dichloro-5-methoxy-
SMILES C1=NC(=C(C(=N1)Cl)OC)Cl

Description

4,6-Dichloro-5-methoxypyrimidine serves as a pivotal building block in heterocyclic synthesis, featuring two electrophilic chlorine sites flanking a methoxy-substituted pyrimidine core. This configuration enables selective substitution reactions under mild conditions, facilitating the construction of complex pharmaceutical intermediates and functionalized nucleosides with high regiocontrol.

Application

4,6-Dichloro-5-methoxypyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through nucleophilic substitution. The dichloro functionality offers orthogonal reactivity for sequential functionalization, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable solid form facilitates handling and purification, making it well-suited for scalable synthesis of API intermediates and heterocyclic libraries.

Synthesis

Route1
- 5193-84-0
- ~84%
- In-stock
  
  5018-38-2
References
- ARENA PHARMACEUTICALS, INC. Patent: US2009/286816 A1, 2009 ; Location in patent: Page/Page column 12 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

TPSA 35.01
LogP 1.792
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4,6-Dichloro-5-methoxypyrimidine

CAS No. 5018-38-2

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