2,4,6-Trichloro-5-methoxypyrimidine

Name: 2,4,6-Trichloro-5-methoxypyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 60703-46-0
Cat. No. CS-W007203
Purity≥96%
MDL No.MFCD11226168

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4,6-Trichloro-5-methoxypyrimidine|CS-W007203

Structure of 60703-46-0

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General Information

CAS No. 60703-46-0
Cat. No. CS-W007203
Purity ≥96%
MDL No. MFCD11226168
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃Cl₃N₂O
Molecular Weight 213.45
Synonym(s) None
SMILES COC1=C(Cl)N=C(Cl)N=C1Cl

Description

2,4,6-Trichloro-5-methoxypyrimidine serves as a pivotal electrophilic scaffold in heterocyclic synthesis. The methoxy group at the 5-position enhances solubility and directs regioselective functionalization. This bench-stable pyrimidine derivative facilitates efficient coupling reactions under mild conditions, enabling rapid access to complex nitrogen-containing architectures.

Application

2,4,6-Trichloro-5-methoxypyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its three chlorines provide orthogonal reactivity for sequential nucleophilic substitutions, facilitating the installation of diverse aryl, alkyl, and amine functionalities under mild conditions. The methoxy group enhances solubility and stability, supporting reliable handling and purification. Widely used in medicinal chemistry and agrochemical development, it functions as a key intermediate for functionalized pyrimidines with proven utility in drug discovery workflows.

Synthesis

Route1
- 71720-62-2
- ~81%
- In-stock
  
  60703-46-0
References
- F. HOFFMANN-LA-ROCHE AG; DOTSON, Jennafer; HEALD, Robert Andrew; HEFFRON, Timothy; JONES, Graham Elgin; KRINTEL, Sussie Lerche; MCLEAN, Neville James; NDUBAKU, Chudi; OLIVERO, Alan G.; SALPHATI, Laurent; WANG, Lan; WEI, BinQing Patent: WO2012/82997 A1, 2012 ; Location in patent: Page/Page column 84 ; WO 2012/082997 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.01
LogP 2.4454
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,4,6-Trichloro-5-methoxypyrimidine

CAS No. 60703-46-0

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