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CS-W001157 4
Total: USD 88.00

2,4-dichloropyrimidin-5-ol

  • CAS No. 1395037-19-0

  • Cat. No. CS-W004351
  • Purity≥95%
  • MDL No.MFCD22570332

*For research and further manufacturing use only, not for direct human use.

2,4-dichloropyrimidin-5-ol|CS-W004351

Structure of 1395037-19-0

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General Information

  • CAS No. 1395037-19-0
  • Cat. No. CS-W004351
  • Purity ≥95%
  • MDL No. MFCD22570332
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂O
  • Molecular Weight 164.98
  • Synonym(s) 2,4-Dichloro-5-pyrimidinol
  • SMILES Clc1ncc(c(n1)Cl)O

Description

2,4-Dichloropyrimidin-5-ol serves as a key heterocyclic building block in medicinal chemistry, featuring two chlorine substituents at electron-deficient positions that enhance reactivity in nucleophilic substitution. The hydroxyl group enables direct functionalization or hydrogen bonding in target interactions. This compound exhibits bench-stable handling and compatibility with diverse reaction conditions.

Application

2,4-Dichloropyrimidin-5-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. The dichloro functionality allows selective displacement under mild conditions, facilitating the installation of diverse amine- and thiol-based side chains. Its bench-stable crystalline form simplifies handling and purification, while the hydroxyl group provides a handle for further derivatization. Widely employed in kinase inhibitor and antiviral agent synthesis, it functions as a key intermediate in standard coupling workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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