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CS-W001157 4
Total: USD 88.00

5-Fluoropyridin-3-amine

  • CAS No. 210169-05-4

  • Cat. No. CS-W008078
  • Purity≥97%
  • MDL No.MFCD00234073

*For research and further manufacturing use only, not for direct human use.

5-Fluoropyridin-3-amine|CS-W008078

Structure of 210169-05-4

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General Information

  • CAS No. 210169-05-4
  • Cat. No. CS-W008078
  • Purity ≥97%
  • MDL No. MFCD00234073
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅FN₂
  • Molecular Weight None
  • Synonym(s) 3-Amino-5-fluoropyridine
  • SMILES NC1=CC(=CN=C1)F

Description

5-Fluoropyridin-3-amine features a fluorine atom at the 5-position and an amino group at the 3-position of a pyridine ring, delivering a potent electron-deficient heteroaromatic scaffold. This configuration enables direct incorporation into pharmaceutical intermediates, facilitating coupling reactions and enabling access to bioactive molecules through transition-metal-catalyzed transformations.

Application

5-Fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into diverse heterocyclic scaffolds. Its reactivity is well-documented in cross-coupling and nucleophilic substitution reactions, particularly with aryl halides and sulfonyl chlorides. The molecule exhibits excellent bench stability and facilitates efficient purification, making it ideal for multi-step synthesis workflows targeting kinase inhibitors and other bioactive compounds.

Synthesis

  • Route1
    • null|null
      247235-86-5
    • ~97%
    • In-stock
      5-Fluoropyridin-3-amine|CS-W008078
      210169-05-4

    References

    • O'Connor, Stephen J.; Barr, Kenneth J.; Wang, Le; Sorensen, Bryan K.; Tasker, Andrew S.; Sham, Hing; Shi-Chung, Ng; Cohen, Jerome; Devine, Edward; Cherian, Sajeev; Saeed, Badr; Zhang, Haichao; Jang Yun, Lee; Warner, Robert; Tahir, Stephen; Kovar, Peter; Ewing, Patricia; Alder, Jeffrey; Mitten, Michael; Leal, Juan; Marsh, Kennan; Bauch, Joy; Hoffman, Daniel J.; Sebti, Said M.; Rosenberg, Saul H. Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3701 - 3710
  • Route2
    • null|null
      210169-04-3
    • ~%
    • In-stock
      5-Fluoropyridin-3-amine|CS-W008078
      210169-05-4

    References

    • Journal of the Chemical Society - Perkin Transactions 1, , # 10 p. 1705 - 1713
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 42, # 18 p. 3701 - 3710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.8029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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