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CS-W001157 4
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5-Amino-2-methoxypyridine

  • CAS No. 6628-77-9

  • Cat. No. CS-W001994
  • Purity≥97%
  • MDL No.MFCD00006264

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-methoxypyridine|CS-W001994

Structure of 6628-77-9

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General Information

  • CAS No. 6628-77-9
  • Cat. No. CS-W001994
  • Purity ≥97%
  • MDL No. MFCD00006264
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) None
  • SMILES COC(C=C1)=NC=C1N

Description

5-Amino-2-methoxypyridine is a heterocyclic amine featuring an electron-rich pyridine core with strategically positioned amino and methoxy substituents. This combination enables efficient coupling in cross-coupling reactions and facilitates coordination in transition metal catalysis. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions, making it well-suited for use in pharmaceutical intermediates and functional material synthesis.

Application

5-Amino-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard coupling and functionalization reactions. Its ortho-directed reactivity facilitates regioselective transformations, while the amino and methoxy groups offer complementary handles for derivatization. The compound exhibits good bench stability and is readily purified by recrystallization, supporting reliable use in multi-step synthesis workflows.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 24 p. 6265 - 6273
  • Route2

    References

    • Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034
  • Route3
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      342793-48-0
    • ~%
    • In-stock
      5-Amino-2-methoxypyridine|CS-W001994
      6628-77-9

    References

    • Journal of Organic Chemistry, , vol. 77, # 16 p. 6908 - 6916

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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