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CS-W001157 4
Total: USD 88.00

6-Aminoindole

  • CAS No. 5318-27-4

  • Cat. No. CS-W001584
  • Purity≥97%
  • MDL No.MFCD02093959

*For research and further manufacturing use only, not for direct human use.

6-Aminoindole|CS-W001584

Structure of 5318-27-4

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General Information

  • CAS No. 5318-27-4
  • Cat. No. CS-W001584
  • Purity ≥97%
  • MDL No. MFCD02093959
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) None
  • SMILES NC1=CC2=C(C=CN2)C=C1

Application

1H-Indol-6-amine serves as a versatile building block in medicinal chemistry, enabling direct access to indole-based scaffolds through standard amine functionalization. Its bench-stable nature and compatibility with common coupling reactions facilitate efficient synthesis of substituted indoles. The primary amine group supports diverse transformations—such as acylation, alkylation, and reductive amination—while maintaining orthogonality to common protecting groups. This makes it particularly useful for constructing biologically relevant heterocycles and peptide conjugates in drug discovery workflows.

Synthesis

  • Route1

    References

    • Carruthers, Nicholas I.; Chai, Wenying; Dax, Scott L.; Jablonowski, Jill A.; Li, Xiaobing; Lovenberg, Timothy W.; Murray, William V.; Rudolph, Dale A.; Seierstad, Mark; Youngman, Mark A. Patent: US2005/70534 A1, 2005 ; Location in patent: Page/Page column 14 ; US 20050070534 A1
  • Route2
    • null|null
      61293-29-6
    • ~65%
    • In-stock
      6-Aminoindole|CS-W001584
      5318-27-4

    References

    • Toste, F. Dean; Still, I. W. J. Organic Preparations and Procedures International, 1995 , vol. 27, # 5 p. 576 - 579
  • Route3
    • null|null
      121-14-2
    • ~%
    • In-stock
      6-Aminoindole|CS-W001584
      5318-27-4

    References

    • Organic Preparations and Procedures International, , vol. 27, # 5 p. 576 - 579

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.81
  • LogP   1.7501
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   0

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