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CS-W001157 4
Total: USD 88.00

1-Boc-6-amino-indole

  • CAS No. 219508-62-0

  • Cat. No. CS-W000608
  • Purity≥97%
  • MDL No.MFCD04114745

*For research and further manufacturing use only, not for direct human use.

1-Boc-6-amino-indole|CS-W000608

Structure of 219508-62-0

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General Information

  • CAS No. 219508-62-0
  • Cat. No. CS-W000608
  • Purity ≥97%
  • MDL No. MFCD04114745
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆N₂O₂
  • Molecular Weight 232.28
  • Synonym(s) tert-Butyl 6-amino-1H-indole-1-carboxylate
  • SMILES Nc1ccc2c(c1)n(cc2)C(=O)OC(C)(C)C

Description

1-Boc-6-amino-indole features a protected amine at the 6-position of the indole scaffold, enabling stable incorporation into peptide and heterocyclic syntheses. The Boc group ensures compatibility with standard deprotection protocols while maintaining solubility under routine reaction conditions. This derivative serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive natural product analogs.

Application

1-Boc-6-amino-indole serves as a versatile building block in medicinal chemistry, enabling efficient access to indole-based scaffolds. The Boc group provides excellent stability and orthogonal protection for the amine, facilitating subsequent functionalization via standard deprotection and coupling reactions. Its compatibility with diverse reaction conditions supports its use in peptide conjugation, heterocycle synthesis, and late-stage derivatization within multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.25
  • LogP   3.0067
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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