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CS-W001157 4
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3-Aminophenol hydrochloride

  • CAS No. 51-81-0

  • Cat. No. CS-W014386
  • Purity≥98%
  • MDL No.MFCD00060221

*For research and further manufacturing use only, not for direct human use.

3-Aminophenol hydrochloride|CS-W014386

Structure of 51-81-0

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General Information

  • CAS No. 51-81-0
  • Cat. No. CS-W014386
  • Purity ≥98%
  • MDL No. MFCD00060221
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈ClNO
  • Molecular Weight 145.59
  • Synonym(s) 3-Aminophenol hydrochlorid
  • SMILES OC1=CC=CC(N)=C1.[H]Cl

Description

3-Aminophenol hydrochloride serves as a key intermediate in pharmaceutical synthesis, featuring a primary amine and phenolic hydroxyl group in close proximity. This arrangement enables direct coupling reactions under mild conditions, facilitating the construction of complex heterocyclic scaffolds. The salt form enhances solubility in aqueous and polar organic media, supporting efficient processing during multi-step sequences.

Application

3-Aminophenol hydrochloride serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct access to substituted anilines and heterocycles. Its stability under ambient conditions and ease of purification facilitate integration into multi-step sequences. The compound reacts predictably with electrophiles, acylating agents, and coupling partners, making it suitable for peptide analogs, dye intermediates, and API scaffolds requiring ortho-amino phenolic motifs.

Synthesis

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      3-Aminophenol hydrochloride|CS-W014386
      51-81-0

    References

    • YALE UNIVERSITY Patent: WO2007/38387 A2, 2007 ; Location in patent: Page/Page column 45 ;
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      3-Aminophenol hydrochloride|CS-W014386
      51-81-0

    References

    • Ikramuddeen; Chandrasekara; Ramarajan; Subramania n Journal of the Indian Chemical Society, 1989 , vol. 66, # 5 p. 342 - 344
  • Route3
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      62276-01-1
    • In-stock
      3-Aminophenol hydrochloride|CS-W014386
      51-81-0

    References

    • Ikramuddeen; Chandrasekara; Ramarajan; Subramania n Journal of the Indian Chemical Society, 1989 , vol. 66, # 5 p. 342 - 344

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.3962
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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