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CS-W001157 4
Total: USD 88.00

Furo[3,2-b]pyridine

  • CAS No. 272-62-8

  • Cat. No. CS-0049346
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Furo[3,2-b]pyridine|CS-0049346

Structure of 272-62-8

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General Information

  • CAS No. 272-62-8
  • Cat. No. CS-0049346
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO
  • Molecular Weight 119.12
  • Synonym(s) None
  • SMILES O1C=CC2=C1C=CC=N2

Description

Furo[3,2-b]pyridine is a heteroaromatic scaffold integrating furan and pyridine rings, offering enhanced electron-deficient character and planarity. This structural rigidity supports applications in conjugated materials and as a building block for bioactive compounds, enabling efficient coupling in synthetic workflows under standard conditions.

Application

Furo[3,2-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic chemistry. Its fused tricyclic structure provides inherent stability and favorable electronic properties, enabling efficient functionalization at multiple positions. The scaffold exhibits excellent compatibility with standard coupling reactions and serves as a key core in the synthesis of bioactive compounds and advanced pharmaceutical intermediates.

Synthesis

  • Route1
    • 2-Bromopyridin-3-yl acetate|CS-0051984
      92671-70-0
    • ~21%
    • In-stock
      Furo[3,2-b]pyridine|CS-0049346
      272-62-8

    References

    • ARRAY BIOPHARMA INC. Patent: WO2005/51304 A2, 2005 ; Location in patent: Page/Page column 144 ; WO 2005/051304 A2
  • Route2
    • 6-Bromofuro[3,2-b]pyridine|CS-0312922
      934330-61-7
    • null|null
      823-96-1
    • ~%
    • In-stock
      Furo[3,2-b]pyridine|CS-0049346
      272-62-8
    • 6-Methylfuro[3,2-b]pyridine|CS-0894326
      1312556-69-6

    References

    • NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk Patent: WO2011/73316 A1, 2011 ; Location in patent: Page/Page column 69-70 ; WO 2011/073316 A1
  • Route3
    • 2,3-Dihydrofuro[3,2-b]pyridin-3-ol|CS-0112101
      107096-01-5
    • ~93%
    • In-stock
      Furo[3,2-b]pyridine|CS-0049346
      272-62-8

    References

    • Shiotani, Shunsaku; Morita, Hiroyuki Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 665 - 668

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.03
  • LogP   1.8278
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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