Lot numbers can be found on the outside label of a product:
4,6-Dibromopyridin-2-amine
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CAS No. 408352-48-7
- Cat. No. CS-0108768
- Purity≥98%
- MDL No.MFCD18447569
*For research and further manufacturing use only, not for direct human use.
Structure of 408352-48-7
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General Information
- CAS No. 408352-48-7
- Cat. No. CS-0108768
- Purity ≥98%
- MDL No. MFCD18447569
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄Br₂N₂
- Molecular Weight 251.91
- Synonym(s) 2-amino-4,6-dibromopyridine
- SMILES NC1=NC(Br)=CC(Br)=C1
Description
4,6-Dibromopyridin-2-amine features two bromine substituents at the 4 and 6 positions of the pyridine ring, flanking a strategically placed amine group. This arrangement enables direct coupling in cross-coupling reactions, delivering functionalized heterocycles with high regiocontrol. The molecule exhibits robust stability under standard conditions and integrates readily into synthetic sequences requiring halogenated building blocks.
Application
4,6-Dibromopyridin-2-amine serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling reactions. The strategically positioned bromine atoms facilitate sequential functionalization, while the amino group provides a handle for derivatization or metal coordination. Its bench-stable nature and compatibility with standard coupling protocols make it a practical choice for constructing complex heterocyclic architectures in API development and advanced synthetic workflows.
Synthesis
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Route1
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In-stock
2408-70-0 - ~%
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In-stock
408352-48-7
References
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den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 129,136 Full Text Show Details den Hertog; Jouwersma Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 44,47
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References
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den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 129,136 Full Text Show Details den Hertog; Jouwersma Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 44,47
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Route3
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504-29-0 - ~1%
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In-stock
1072-97-5 -
In-stock
408352-48-7
References
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Berthelot, Jacques; Guette, Catherine; Desbene, Paul-Louis; Basselier, Jean-Jacques; Chaquin, Patrick; Masure, Daniel Canadian Journal of Chemistry, 1989 , vol. 67, p. 2061 - 2066
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 2.1888
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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