6-Bromo-4-chloropyridin-2-amine

Name: 6-Bromo-4-chloropyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1206249-65-1
Cat. No. CS-0130963
Purity≥95%
MDL No.MFCD14582019

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-4-chloropyridin-2-amine|CS-0130963

Structure of 1206249-65-1

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Description

6-Bromo-4-chloropyridin-2-amine features a pyridine core functionalized with bromo and chloro substituents at the 6- and 4-positions, respectively, and an amino group at the 2-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry for constructing kinase inhibitors and bioactive scaffolds. The molecule exhibits enhanced reactivity in palladium-catalyzed cross-coupling reactions due to the orthogonal halogenation pattern, enabling selective functionalization. Its bench-stable nature facilitates handling under standard conditions.

Application

6-Bromo-4-chloropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo and chloro substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Its stability under standard reaction conditions and compatibility with diverse coupling partners make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 1206249-65-1
Cat. No. CS-0130963
Purity ≥95%
MDL No. MFCD14582019
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrClN₂
Molecular Weight 207.46
Synonym(s) 6-Bromo-4-chloro-pyridin-2-ylamine
SMILES NC1=NC(Br)=CC(Cl)=C1

Computational Chemistry Data

TPSA 38.91
LogP 2.0797
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-4-chloropyridin-2-amine

CAS No. 1206249-65-1

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