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CS-W001157 4
Total: USD 88.00

1-Cyclobutyl-1H-pyrazole-4-carbaldehyde

  • CAS No. 1545675-69-1

  • Cat. No. CS-0654678
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclobutyl-1H-pyrazole-4-carbaldehyde|CS-0654678

Structure of 1545675-69-1

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General Information

  • CAS No. 1545675-69-1
  • Cat. No. CS-0654678
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O
  • Molecular Weight 150.18
  • Synonym(s) None
  • SMILES C1CC(C1)N2C=C(C=N2)C=O

Description

1-Cyclobutyl-1H-pyrazole-4-carbaldehyde features a pyrazole core bearing a cyclobutyl substituent and an aldehyde handle at the 4-position. This electron-deficient aldehyde integrates readily into diversification workflows, offering a rigid, sterically constrained scaffold for medicinal chemistry and materials synthesis under standard conditions.

Application

1-Cyclobutyl-1H-pyrazole-4-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds. Its aldehyde functionality facilitates nucleophilic additions, reductive aminations, and Ugi-type reactions with high functional group tolerance. The cyclobutyl substituent enhances metabolic stability and modulates lipophilicity, making it valuable in medicinal chemistry lead optimization. Bench-stable and readily purified by flash chromatography, it functions reliably in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.4206
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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