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CS-W001157 4
Total: USD 88.00

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde

  • CAS No. 1216244-84-6

  • Cat. No. CS-0438088
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde|CS-0438088

Structure of 1216244-84-6

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General Information

  • CAS No. 1216244-84-6
  • Cat. No. CS-0438088
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₂N₂O
  • Molecular Weight 146.09
  • Synonym(s) None
  • SMILES O=CC1=CN(C(F)F)N=C1

Description

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde features a unique difluoromethyl group attached to a pyrazole scaffold, delivering enhanced metabolic stability and altered electronic properties. This electron-deficient aldehyde integrates readily into bioactive molecule synthesis, enabling efficient coupling reactions under mild conditions. The conjugated system supports precise tuning of reactivity in medicinal chemistry applications.

Application

1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde serves as a versatile building block for fluorinated heterocycles, enabling efficient access to bioactive scaffolds via standard condensation and coupling reactions. Its difluoromethyl group enhances metabolic stability and modulates electronic properties, while the aldehyde functionality supports facile derivatization under mild conditions. The compound exhibits excellent bench stability and compatibility with common protecting groups, facilitating its use in medicinal chemistry and process-oriented synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.0907
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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