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CS-W001157 4
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6-(tert-Butyl)pyridin-3-amine

  • CAS No. 39919-70-5

  • Cat. No. CS-0072385
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(tert-Butyl)pyridin-3-amine|CS-0072385

Structure of 39919-70-5

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General Information

  • CAS No. 39919-70-5
  • Cat. No. CS-0072385
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₂
  • Molecular Weight 150.22
  • Synonym(s) 3-Pyridinamine,6-(1,1-dimethylethyl)-(9CI)
  • SMILES NC1=CN=C(C=C1)C(C)(C)C

Description

6-(tert-Butyl)pyridin-3-amine features a sterically hindered tert-butyl group positioned para to a primary amine on the pyridine ring, enhancing solubility and stability. This electronic and steric profile enables efficient coupling in transition metal catalysis and facilitates incorporation into functionalized ligands and pharmaceutical intermediates under standard conditions.

Application

6-(tert-Butyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its tert-butyl group enhances solubility and steric shielding, while the pyridine nitrogen and primary amine offer orthogonal functionalization sites. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis and scale-up in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.9613
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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