2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile

Name: 2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1226776-95-9
Cat. No. CS-W003879
Purity≥98%
MDL No.MFCD16495866

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile|CS-W003879

Structure of 1226776-95-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1226776-95-9
Cat. No. CS-W003879
Purity ≥98%
MDL No. MFCD16495866
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₁N₃
Molecular Weight 161.20
Synonym(s) 5-amino-α,α-dimethyl-2-Pyridineacetonitrile
SMILES CC(C#N)(C1=NC=C(N)C=C1)C

Description

This nitrile features a 5-aminopyridin-2-yl group attached to a sterically hindered methylpropanenitrile scaffold, enabling efficient coupling in transition-metal-catalyzed transformations. The electron-rich pyridine ring enhances reactivity in cross-coupling protocols, while the bench-stable nitrile moiety simplifies handling and purification.

Application

2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its nitrile group offers high stability and compatibility with diverse reaction conditions, while the ortho-aminopyridine moiety facilitates further derivatization via electrophilic substitution or metal-catalyzed cross-coupling. The tert-butyl nitrile functionality provides excellent bench stability and simplifies purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- 1256633-31-4
- ~63%
- In-stock
  
  1226776-95-9
References
- Su, Weiguo; Zhang, Weihan; Yang, Haibin Patent: US2013/190307 A1, 2013 ; Location in patent: Paragraph 0146; 0150 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 62.7
LogP 1.46498
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

1226776-95-9 sigma1226776-95-9 manufacturer1226776-95-9 price1226776-95-9 structure1226776-95-9 SDSbuy 1226776-95-91226776-95-9 supplier1226776-95-9 uses1226776-95-9 molecular weightprice of 1226776-95-91226776-95-9 chemical name formula of 1226776-95-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-(5-Aminopyridin-2-yl)-2-methylpropanenitrile

CAS No. 1226776-95-9

Recommended Products