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CS-W001157 4
Total: USD 88.00

4-Methylpiperidin-4-ol

  • CAS No. 3970-68-1

  • Cat. No. CS-W004838
  • Purity≥97%
  • MDL No.MFCD11100993

*For research and further manufacturing use only, not for direct human use.

4-Methylpiperidin-4-ol|CS-W004838

Structure of 3970-68-1

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General Information

  • CAS No. 3970-68-1
  • Cat. No. CS-W004838
  • Purity ≥97%
  • MDL No. MFCD11100993
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight 115.17
  • Synonym(s) 4-piperidinol, 4-methyl-
  • SMILES CC1(O)CCNCC1

Description

4-Methylpiperidin-4-ol is a sterically hindered, bench-stable piperidine derivative featuring a hydroxyl group at the 4-position and a methyl substituent on the same nitrogen. This configuration imparts enhanced solubility in polar solvents and facilitates its use as a building block in medicinal chemistry. The molecule integrates readily into complex scaffolds due to its amphoteric character and low nucleophilicity, making it valuable for synthesizing bioactive compounds under standard conditions.

Application

4-Methylpiperidin-4-ol serves as a versatile building block in medicinal chemistry, offering a stable, bench-ready scaffold for the synthesis of bioactive molecules. Its tertiary alcohol functionality enables straightforward derivatization via esterification or ether formation, while the piperidine core provides favorable solubility and metabolic stability. The methyl substitution enhances steric and electronic modulation, facilitating targeted interactions in drug discovery campaigns.

Synthesis

  • Route1

    References

    • CHIESI FARMACEUTICI S.P.A.; VAN NIEL, Monique Bodil; RAY, Nicholas Charles; ALCARAZ, Lilian; PANCHAL, Terry Aaron; JENNINGS, Andrew Stephen Robert; ARMANI, Elisabetta; CRIDLAND, Andrew Peter; HURLEY, Cristopher Patent: WO2013/83604 A1, 2013 ; Location in patent: Page/Page column 278 ;
  • Route2
    • Benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0049826
      169750-57-6
    • ~%
    • In-stock
      4-Methylpiperidin-4-ol|CS-W004838
      3970-68-1

    References

    • Eisai Co., Ltd. Patent: EP1522540 A1, 2005 ; Location in patent: Page/Page column 53 ; EP 1522540 A1
  • Route3
    • 1-Benzyl-4-methylpiperidin-4-ol|CS-0279387
      3970-66-9
    • ~65%
    • In-stock
      4-Methylpiperidin-4-ol|CS-W004838
      3970-68-1

    References

    • Abreo, Melwyn A.; Meng, Jerry J.; Agree, Charles S. Patent: US2002/65292 A1, 2002 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.1208
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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