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CS-W001157 4
Total: USD 88.00

4-Fluoropiperidine

  • CAS No. 78197-27-0

  • Cat. No. CS-0101735
  • Purity≥98%
  • MDL No.MFCD03093851

*For research and further manufacturing use only, not for direct human use.

4-Fluoropiperidine|CS-0101735

Structure of 78197-27-0

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General Information

  • CAS No. 78197-27-0
  • Cat. No. CS-0101735
  • Purity ≥98%
  • MDL No. MFCD03093851
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀FN
  • Molecular Weight 103.14
  • Synonym(s) piperidine, 4-fluoro-
  • SMILES FC1CCNCC1

Description

4-Fluoropiperidine delivers a strategically positioned fluorine atom that enhances metabolic stability and modulates basicity within medicinal chemistry scaffolds. This bench-stable, moisture-tolerant heterocycle integrates readily into bioactive molecules, offering improved membrane permeability and targeted pharmacokinetic profiles in drug discovery campaigns.

Application

4-Fluoropiperidine serves as a valuable building block in medicinal chemistry, enabling the introduction of a fluorinated alkylamine moiety with enhanced metabolic stability and improved membrane permeability. Its well-established reactivity facilitates nucleophilic substitution, amide coupling, and transition-metal-catalyzed transformations. The compound exhibits favorable bench stability and compatibility with common protecting group strategies, making it ideal for modular synthesis of bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • Benzyl 4-fluoropiperidine-1-carboxylate|CS-0069652
      690257-75-1
    • ~%
    • In-stock
      4-Fluoropiperidine|CS-0101735
      78197-27-0

    References

    • WO2005/116029 A1, ; Page/Page column 52 ; WO 2005/116029 A1
  • Route2
    • 1-N-Boc-4-Fluoropiperidine|CS-W001476
      178181-55-0
    • ~%
    • In-stock
      4-Fluoropiperidine|CS-0101735
      78197-27-0

    References

    • Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2906 - 2916
  • Route3
    • null|null
      109384-19-2
    • ~%
    • In-stock
      4-Fluoropiperidine|CS-0101735
      78197-27-0

    References

    • Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2906 - 2916

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2920
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.7079
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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