Lot numbers can be found on the outside label of a product:
Boc-4-Abz-OH
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CAS No. 66493-39-8
- Cat. No. CS-W007493
- Purity≥98%
- MDL No.MFCD00037428
*For research and further manufacturing use only, not for direct human use.
Structure of 66493-39-8
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General Information
- CAS No. 66493-39-8
- Cat. No. CS-W007493
- Purity ≥98%
- MDL No. MFCD00037428
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₅NO₄
- Molecular Weight 237.25
- Synonym(s) 4-[(tert-butoxycarbonyl)amino]benzoic acid
- SMILES O=C(O)C1=CC=C(NC(OC(C)(C)C)=O)C=C1
Description
Boc-4-Abz-OH is a bench-stable, moisture-tolerant building block featuring a protected amine and a para-aminobenzoic acid (Abz) chromophore. This derivative integrates seamlessly into peptide synthesis workflows, enabling site-specific labeling or fluorescent tagging in bioconjugation applications.
Application
Boc-4-Abz-OH serves as a versatile building block for peptide synthesis and peptidomimetic design, enabling efficient incorporation of the 4-aminobenzoic acid (4-Abz) moiety. The Boc group provides orthogonal protection for the amine, allowing selective deprotection under mild acidic conditions. This derivative exhibits excellent bench stability, facilitates straightforward purification, and participates reliably in standard coupling reactions, making it ideal for constructing bioactive peptides and heterocyclic scaffolds in medicinal chemistry workflows.
Synthesis
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Route1
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In-stock
24424-99-5 -
150-13-0 - ~97%
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In-stock
66493-39-8
References
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Mu; Coffing; Riese II; Geahlen; Verdier-Pinard; Hamel; Johnson; Cushman Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 441 - 452
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Route2
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In-stock
110969-44-3 - ~38%
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In-stock
66493-39-8
References
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Eli Lilly and Company Patent: US6639107 B1, 2003 ; Location in patent: Page/Page column 36 ;
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Route3
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In-stock
24424-99-5
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6427-66-3 - ~89%
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In-stock
66493-39-8
References
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Chandrasekhar; Chandraiah; Raji Reddy; Venkat Reddy Chemistry Letters, 2000 , # 7 p. 780 - 781
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 75.63
- LogP 2.7318
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 2
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Key Words
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