4-((tert-Butoxycarbonyl)(methyl)amino)benzoic acid

Name: 4-((tert-Butoxycarbonyl)(methyl)amino)benzoic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 263021-30-3
Cat. No. CS-W010212
Purity≥97%
MDL No.MFCD04972273

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-((tert-Butoxycarbonyl)(methyl)amino)benzoic acid|CS-W010212

Structure of 263021-30-3

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 263021-30-3
Cat. No. CS-W010212
Purity ≥97%
MDL No. MFCD04972273
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₇NO₄
Molecular Weight 251.28
Synonym(s) Boc-4-Methylaminobenzoic Acid
SMILES O=C(O)C1=CC=C(N(C(OC(C)(C)C)=O)C)C=C1

Description

This tert-butyl ester derivative of a methylaminobenzoic acid integrates a protected amine and carboxylic acid functionality, enabling sequential deprotection and coupling in peptide synthesis. The electron-withdrawing carbonyl group enhances reactivity at the aromatic ring, while the tert-butoxycarbonyl moiety ensures stability under basic conditions and facilitates selective removal during late-stage functionalization.

Application

4-((tert-Butoxycarbonyl)(methyl)amino)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted benzamide derivatives through standard deprotection and coupling protocols. The tert-butyl carbamate group provides orthogonal protection for primary amines, while the carboxylic acid functionality supports direct amide bond formation or esterification. Its bench-stable nature and compatibility with common reaction conditions facilitate efficient multi-step synthesis workflows.

Synthesis

Route1
- In-stock
  
  24424-99-5
- In-stock
  
  10541-83-0
- ~85%
- In-stock
  
  263021-30-3
References
- JANSSEN PHARMACEUTICA N.V. Patent: WO2004/69792 A2, 2004 ; Location in patent: Page 141 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H317-H412
Precautionary Statements : P261-P272-P273-P280-P302+P352-P363-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 66.84
LogP 2.7561
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

263021-30-3 sigma263021-30-3 manufacturer263021-30-3 price263021-30-3 structure263021-30-3 SDSbuy 263021-30-3263021-30-3 supplier263021-30-3 uses263021-30-3 molecular weightprice of 263021-30-3263021-30-3 chemical name formula of 263021-30-3

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-((tert-Butoxycarbonyl)(methyl)amino)benzoic acid

CAS No. 263021-30-3

Recommended Products