3,5-Difluorobenzene-1-sulfonyl chloride

Name: 3,5-Difluorobenzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 210532-25-5
Cat. No. CS-W007629
Purity≥97%
MDL No.MFCD02091378

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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3,5-Difluorobenzene-1-sulfonyl chloride|CS-W007629

Structure of 210532-25-5

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General Information

CAS No. 210532-25-5
Cat. No. CS-W007629
Purity ≥97%
MDL No. MFCD02091378
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂O₂S
Molecular Weight 212.60
Synonym(s) 3,5-Difluorobenzenesulphonyl chloride
SMILES C1=C([S](Cl)(=O)=O)C=C(F)C=C1F

Description

3,5-Difluorobenzene-1-sulfonyl chloride is a bench-stable sulfonyl chloride featuring two fluorine substituents at the 3 and 5 positions of the benzene ring. This electron-deficient aryl moiety enables efficient coupling in sulfonamide synthesis, offering enhanced reactivity and selectivity in amine functionalization under standard conditions.

Application

3,5-Difluorobenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the introduction of a fluorinated sulfonate group under mild conditions. Its high reactivity enables efficient formation of sulfonamides and sulfonic esters with broad functional group tolerance. The electron-withdrawing difluoro substitution enhances electrophilicity while maintaining bench stability, facilitating purification and integration into multi-step synthetic sequences targeting bioactive molecules and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 1.8923
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3,5-Difluorobenzene-1-sulfonyl chloride

CAS No. 210532-25-5

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