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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate

  • CAS No. 406235-30-1

  • Cat. No. CS-0069669
  • Purity≥97%
  • MDL No.MFCD04972471

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0069669

Structure of 406235-30-1

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General Information

  • CAS No. 406235-30-1
  • Cat. No. CS-0069669
  • Purity ≥97%
  • MDL No. MFCD04972471
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₃
  • Molecular Weight 215.29
  • Synonym(s) N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
  • SMILES O=C(N1CCC(C)(O)CC1)OC(C)(C)C

Description

tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate features a sterically shielded piperidine core with a hydroxyl group at the 4-position and a methyl substituent enhancing stability. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures, particularly in medicinal chemistry scaffolds requiring controlled polarity and metabolic resistance.

Application

tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds through standard functional group manipulations. The hydroxyl group facilitates selective derivatization, while the tert-butyl carbamate offers protection and stability under basic conditions. Its bench-stable nature and compatibility with common coupling and reduction protocols make it ideal for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      75-16-1
    • null|null
      79099-07-3
    • ~98%
    • In-stock
      tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0069669
      406235-30-1

    References

    • Journal of the American Chemical Society, , vol. 135, # 41 p. 15342 - 15345
  • Route2
    • null|null
      676-58-4
    • null|null
      79099-07-3
    • ~95%
    • In-stock
      tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0069669
      406235-30-1

    References

    • WO2008/84300 A1, ; Page/Page column 105 ; WO 2008/084300 A1
  • Route3
    • null|null
      917-54-4
    • null|null
      79099-07-3
    • ~94%
    • In-stock
      tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate|CS-0069669
      406235-30-1

    References

    • EP1762568 A1, ; Page/Page column 49 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.7683
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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