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2-[(2r)-1-[(tert-butoxy)carbonyl]piperidin-2-yl]acetic acid

  • CAS No. 351410-32-7

  • Cat. No. CS-0217678
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[(2r)-1-[(tert-butoxy)carbonyl]piperidin-2-yl]acetic acid|CS-0217678

Structure of 351410-32-7

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General Information

  • CAS No. 351410-32-7
  • Cat. No. CS-0217678
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) 2-piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, (2R)-
  • SMILES CC(C)(C)OC(=O)N1CCCC[C@@H]1CC(=O)O

Description

This piperidine-based acetic acid derivative features a tert-butoxycarbonyl-protected amine and a pendant carboxylic acid, enabling direct incorporation into peptide synthesis. The protected nitrogen facilitates efficient coupling reactions under standard conditions, while the aliphatic backbone provides solubility and stability in common organic solvents.

Application

2-[(2R)-1-[(tert-butoxy)carbonyl]piperidin-2-yl]acetic acid serves as a versatile building block for synthesizing bioactive heterocycles and peptidomimetics. Its pendant carboxylic acid enables straightforward coupling reactions, while the Boc-protected piperidine moiety offers stability and orthogonal functionality. The molecule facilitates efficient access to constrained scaffolds relevant in medicinal chemistry, with excellent bench stability and compatibility in standard peptide and combinatorial synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.2507
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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