1-(2-Aminothiazol-5-yl)ethanone

Name: 1-(2-Aminothiazol-5-yl)ethanone
Brand: ChemScene
Availability: InStock
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CAS No. 53159-71-0
Cat. No. CS-0052918
Purity≥97%
MDL No.MFCD00775044

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(2-Aminothiazol-5-yl)ethanone|CS-0052918

Structure of 53159-71-0

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General Information

CAS No. 53159-71-0
Cat. No. CS-0052918
Purity ≥97%
MDL No. MFCD00775044
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆N₂OS
Molecular Weight 142.18
Synonym(s) 1-(2-Amino-1,3-thiazol-5-yl)ethan-1-one
SMILES CC(=O)C1=CN=C(N)S1

Description

1-(2-Aminothiazol-5-yl)ethanone features a reactive acetyl group flanked by a nitrogen-rich thiazole ring, enabling direct incorporation into bioactive scaffolds. This bench-stable derivative serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Application

1-(2-Aminothiazol-5-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its amine and ketone functionalities support diverse transformations, including nucleophilic additions, amidations, and condensation reactions. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting bioactive heterocycles.

Synthesis

Route1
- 87005-15-0
- 17356-08-0
- ~40%
- In-stock
  
  53159-71-0
References
- APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patent: WO2005/68444 A2, 2005 ; Location in patent: Page/Page column 79 ;
Route2
- 83490-20-4
- 78-95-5
- ~%
- In-stock
  
  53159-71-0
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 19 p. 5864 - 5868

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

TPSA 55.98
LogP 0.9279
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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1-(2-Aminothiazol-5-yl)ethanone

CAS No. 53159-71-0

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