1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride

Name: 1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1354940-72-9
Cat. No. CS-D0201
Purity≥95%
MDL No.MFCD18253770

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride|CS-D0201

Structure of 1354940-72-9

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General Information

CAS No. 1354940-72-9
Cat. No. CS-D0201
Purity ≥95%
MDL No. MFCD18253770
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₁ClN₂
Molecular Weight 170.64
Synonym(s) None
SMILES C12=CC=NC=C1CNCC2.Cl

Description

1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride is a bench-stable, moisture-tolerant heterocyclic scaffold featuring a protonated nitrogen at the 2-position. This charged form enhances solubility in aqueous and polar organic media, enabling seamless integration into medicinal chemistry campaigns requiring basic nitrogen functionality.

Application

1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-rich scaffolds. Its stable, crystalline form facilitates handling and purification, while the protonated pyridine nitrogen enhances solubility and reactivity in electrophilic functionalization. The compound functions effectively in transition-metal-catalyzed coupling reactions and serves as a core motif in the synthesis of kinase inhibitors and CNS-targeted small molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 24.92
LogP 1.1491
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1,2,3,4-Tetrahydro-2,7-naphthyridine hydrochloride

CAS No. 1354940-72-9

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