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2-(Piperidin-2-yl)acetic acid hydrochloride

  • CAS No. 19615-30-6

  • Cat. No. CS-0217095
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Piperidin-2-yl)acetic acid hydrochloride|CS-0217095

Structure of 19615-30-6

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General Information

  • CAS No. 19615-30-6
  • Cat. No. CS-0217095
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO₂
  • Molecular Weight 179.64
  • Synonym(s) 2-Piperidylacetic Acid Hydrochloride
  • SMILES C1CCNC(C1)CC(=O)O.Cl

Description

This piperidine-containing acetic acid derivative features a bench-stable, moisture-tolerant hydrochloride salt form that integrates readily into peptide coupling workflows. The pendant piperidin-2-yl group provides enhanced solubility and nucleophilicity, enabling efficient incorporation into bioactive scaffolds and synthetic intermediates for medicinal chemistry applications.

Application

2-(Piperidin-2-yl)acetic acid hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through its readily modifiable carboxylic acid and secondary amine functionalities. The hydrochloride salt enhances bench stability and solubility, facilitating purification and compatibility with standard peptide coupling protocols. It functions as a key intermediate in the construction of piperidine-containing heterocycles and API scaffolds, particularly in CNS-targeted therapeutics and kinase inhibitors.

Synthesis

  • Route1

    References

    • GRUeNENTHAL GMBH Patent: WO2009/124746 A1, 2009 ; Location in patent: Page/Page column 92 ;
  • Route2
    • 2-(Pyridin-2-yl)acetic acid|CS-0096299
      13115-43-0
    • ~%
    • In-stock
      2-(Piperidin-2-yl)acetic acid hydrochloride|CS-0217095
      19615-30-6

    References

    • Liljeblad, Arto; Kavenius, Hanna-Maija; Taehtinen, Petri; Kanerva, Liisa T. Tetrahedron Asymmetry, 2007 , vol. 18, # 2 p. 181 - 191
  • Route3
    • null|null
      61020-07-3
    • ~%
    • In-stock
      2-(Piperidin-2-yl)acetic acid hydrochloride|CS-0217095
      19615-30-6

    References

    • Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 37, # 6 p. 555 - 566

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   1.025
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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