Lot numbers can be found on the outside label of a product:
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid
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CAS No. 154775-43-6
- Cat. No. CS-W001452
- Purity≥97%
- MDL No.MFCD01861212
*For research and further manufacturing use only, not for direct human use.
Structure of 154775-43-6
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General Information
- CAS No. 154775-43-6
- Cat. No. CS-W001452
- Purity ≥97%
- MDL No. MFCD01861212
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₂₃NO₄
- Molecular Weight 257.33
- Synonym(s) None
- SMILES O=C(OC(C)(C)C)N1CCC(CCC(=O)O)CC1
Description
This piperidine-based carboxylic acid features a tert-butoxycarbonyl-protected amine and a flexible propanoic acid side chain, enabling integration into peptide backbones or bioactive molecule scaffolds. The Boc group ensures stability during synthesis, while the aliphatic linker provides conformational flexibility for molecular recognition in drug discovery applications.
Application
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid serves as a versatile building block for the synthesis of bioactive molecules, enabling efficient incorporation of piperidine-containing pharmacophores. The tert-butyl carbamate group provides robust protection for the amine under standard reaction conditions, while the propanoic acid functionality facilitates conjugation via amidation or esterification. This scaffold exhibits excellent bench stability and compatibility with diverse functional groups, supporting straightforward purification and integration into complex molecular architectures.
Synthesis
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Route1
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1822-32-8 -
In-stock
24424-99-5 - ~90%
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In-stock
154775-43-6
References
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Adang, Anton E. P.; Peters, Co A. M.; Gerritsma, Siene; De Zwart, Edwin; Veeneman, Gerrit Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1227 - 1232
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Route2
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In-stock
301232-45-1 - ~90%
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In-stock
154775-43-6
References
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Yamanaka, Toshio; Ohkubo, Mitsuru; Kuroda, Satoru; Nakamura, Hideko; Takahashi, Fumie; Aoki, Toshiaki; Mihara, Kayoko; Seki, Jiro; Kato, Masayuki Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 13 p. 4343 - 4352
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Route3
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In-stock
162504-75-8 - ~89%
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In-stock
154775-43-6
References
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Klein, Scott I.; Molino, Bruce F.; Czekaj, Mark; Gardner, Charles J.; Chu, Valeria; Brown, Karen; Sabatino, Ralph D.; Bostwick, Jeffrey S.; Kasiewski, Charles; Bentley, Ross; Windisch, Vincent; Perrone, Mark; Dunwiddie, Christopher T.; Leadley, Robert J. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2492 - 2502
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 2.4983
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
- 154775-43-6 sigma154775-43-6 manufacturer154775-43-6 price154775-43-6 structure154775-43-6 SDSbuy 154775-43-6154775-43-6 supplier154775-43-6 uses154775-43-6 molecular weightprice of 154775-43-6154775-43-6 chemical name formula of 154775-43-6