Lot numbers can be found on the outside label of a product:
tert-Butyl 3-methylidenepyrrolidine-1-carboxylate
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CAS No. 114214-71-0
- Cat. No. CS-0048277
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 114214-71-0
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General Information
- CAS No. 114214-71-0
- Cat. No. CS-0048277
- Purity ≥97%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₂
- Molecular Weight 183.25
- Synonym(s) Tert-butyl 3-methylenepyrrolidine-1-carboxylate
- SMILES CC(C)(C)OC(=O)N1CCC(=C)C1
Description
tert-Butyl 3-methylidenepyrrolidine-1-carboxylate features a stabilized enol ether moiety flanked by a pyrrolidine ring, enabling direct incorporation into cascade cyclizations and transition-metal-catalyzed transformations. This bench-stable, moisture-tolerant building block facilitates rapid access to nitrogen-containing heterocycles under standard conditions.
Application
tert-Butyl 3-methylidenepyrrolidine-1-carboxylate serves as a versatile pyrrolidine-based building block in synthetic organic chemistry, enabling efficient access to substituted pyrrolidines via mild acid-mediated deprotection or Michael addition. The exocyclic methylene group facilitates conjugate addition reactions, while the tert-butoxycarbonyl (Boc) group provides robust protection under standard conditions. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for medicinal chemistry campaigns and multistep synthesis.
Synthesis
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Route1
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In-stock
2065-66-9 -
101385-93-7 - ~61%
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In-stock
114214-71-0
References
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Asinex Limited; KAZULKIN, Denis Nikolaevich; KOCHUBEY, Valeriy Sergeevich Patent: EP2719696 A1, 2014 ; Location in patent: Paragraph 0210; 0211 ;
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Route2
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1779-49-3
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101385-93-7
- ~51%
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In-stock
114214-71-0
References
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JANSSEN PHARMACEUTICA NV; BREITENBUCHER, Guy, J.; TICHENOR, Mark, S.; MERIT, Jeffrey, E.; HAWRYLUK, Natalie, A.; CHAMBERS, Alison, L.; KEITH, John, M. Patent: WO2010/141809 A1, 2010 ; Location in patent: Page/Page column 64 ; WO 2010/141809 A1
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Route3
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101385-93-7
- ~%
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In-stock
114214-71-0
References
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US2007/208001 A1, ; Page/Page column 34 ; US 20070208001 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.54
- LogP 2.1834
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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