Lot numbers can be found on the outside label of a product:
6-Methylpyrimidin-4-amine
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CAS No. 3435-28-7
- Cat. No. CS-D1591
- Purity≥98%
- MDL No.MFCD00188073
*For research and further manufacturing use only, not for direct human use.
Structure of 3435-28-7
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General Information
- CAS No. 3435-28-7
- Cat. No. CS-D1591
- Purity ≥98%
- MDL No. MFCD00188073
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₇N₃
- Molecular Weight 109.13
- Synonym(s) 6-Methyl-4-pyrimidinamine; (6-Methylpyrimidin-4-yl)amine; 4-Amino-6-methylpyrimidine; 4-Pyrimidinamine,6-methyl
- SMILES NC1=NC=NC(C)=C1
Description
6-Methylpyrimidin-4-amine features a methyl-substituted pyrimidine core with a primary amine at the 4-position, delivering enhanced solubility and stability under standard conditions. This electron-rich heterocycle serves as a key scaffold in medicinal chemistry, integrating readily into kinase inhibitors and antiviral agents through robust coupling reactions.
Application
6-Methylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. Its methyl group enhances metabolic stability, while the amino functionality facilitates diverse transformations including Suzuki couplings, Buchwald–Hartwig aminations, and direct functionalization. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for iterative synthesis campaigns and API development workflows.
Synthesis
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Route1
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In-stock
1118-61-2 -
149-73-5 - ~26%
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In-stock
3435-28-7
References
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Nishino, Shigeyoshi; Hirotsu, Kenji; Shima, Hidetaka; Harada, Takashi Patent: US2008/45712 A1, 2008 ; Location in patent: Page/Page column 4 ;
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Route2
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In-stock
3435-25-4 - ~%
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In-stock
3435-28-7
References
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Chemische Berichte, , vol. 32, p. 2934 Chemische Berichte, , vol. 35, p. 1570
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Route3
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In-stock
5424-21-5 - ~%
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In-stock
3435-28-7
References
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Journal of the Chemical Society, , p. 1004,1015 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, vol. 24, p. 84
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.8
- LogP 0.36722
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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