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Structure of 50840-23-8
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5-Methylpyrimidin-2-amine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a methyl group at the 5-position that enhances lipophilicity and metabolic stability. The pyrimidine core provides a rigid, electron-deficient platform for hydrogen bonding and π-stacking interactions. This compound integrates readily into kinase inhibitors and antiviral agents due to its ability to occupy hydrophobic pockets within target proteins. Its bench-stable nature supports straightforward handling in synthetic workflows.
5-Methylpyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds through standard coupling and functionalization reactions. Its moderate basicity and bench-stable nature facilitate straightforward handling and purification. The methyl group enhances metabolic stability, while the amino functionality supports derivatization in Suzuki-Miyaura, Ullmann, or amide-forming transformations. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: