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CS-W001157 4
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6-Methylpyrazin-2-amine

  • CAS No. 5521-56-2

  • Cat. No. CS-W005339
  • Purity≥97%
  • MDL No.MFCD08235193

*For research and further manufacturing use only, not for direct human use.

6-Methylpyrazin-2-amine|CS-W005339

Structure of 5521-56-2

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General Information

  • CAS No. 5521-56-2
  • Cat. No. CS-W005339
  • Purity ≥97%
  • MDL No. MFCD08235193
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) 2-AMINE-6-METHYLPYRAZINE
  • SMILES CC1=CN=CC(=N1)N

Description

6-Methylpyrazin-2-amine features a pyrazine core with methyl and amino substituents at the 6- and 2-positions, respectively. This electron-rich heterocycle exhibits enhanced solubility and stability under standard conditions, enabling straightforward integration into medicinal chemistry campaigns. The para-amino group facilitates conjugation in multistep syntheses.

Application

6-Methylpyrazin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazine-based scaffolds through standard functional group manipulations. Its amine functionality facilitates coupling reactions and derivatization under mild conditions, while the methyl group enhances metabolic stability. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Colbon, Paul J. J.; Foster, Alison C.; Giles, Melvyn E.; Patel, Zakariya; Singleton, John T. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1451 - 1456
  • Route2
    • null|null
      544-97-8
    • In-stock
      2-Amino-6-chloropyrazine|CS-D1094
      33332-28-4
    • ~50%
    • In-stock
      6-Methylpyrazin-2-amine|CS-W005339
      5521-56-2

    References

    • Walters, Iain A.S. Tetrahedron Letters, 2006 , vol. 47, # 3 p. 341 - 344
  • Route3

    References

    • Sato, Nobuhiro Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 143 - 147

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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