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CS-W001157 4
Total: USD 88.00

4-Chloro-6-methylpyrimidine

  • CAS No. 3435-25-4

  • Cat. No. CS-W002939
  • Purity≥98%
  • MDL No.MFCD02322991

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methylpyrimidine|CS-W002939

Structure of 3435-25-4

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General Information

  • CAS No. 3435-25-4
  • Cat. No. CS-W002939
  • Purity ≥98%
  • MDL No. MFCD02322991
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight 128.56
  • Synonym(s) 4-Chlor-6-methyl-pyrimidin
  • SMILES Cc1ncnc(c1)Cl

Description

4-Chloro-6-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at the 4-position and a methyl group at the 6-position. This combination imparts enhanced electronic modulation and metabolic stability, enabling efficient integration into kinase inhibitors and antiviral agents. The compound exhibits excellent bench stability and compatibility with diverse coupling reactions.

Application

4-Chloro-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution under mild conditions, while the methyl group provides steric and electronic modulation. The compound exhibits excellent bench stability and is compatible with diverse functional groups, simplifying purification and scale-up in API development workflows.

Synthesis

  • Route1
    • In-stock
      4,6-Dichloropyrimidine|CS-W018513
      1193-21-1
    • null|null
      676-58-4
    • ~%
    • In-stock
      4-Chloro-6-methylpyrimidine|CS-W002939
      3435-25-4

    References

    • WO2011/63272 A1, ; Page/Page column 46 ; WO 2011/063272 A1
  • Route2

    References

    • US2003/22887 A1, ;
  • Route3

    References

    • Synthesis, , # 21 art. no. T60411SS, p. 3496 - 3506

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.43842
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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