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CS-W001157 4
Total: USD 88.00

2,3-Dichloro-5,6-dimethylpyrazine

  • CAS No. 32493-79-1

  • Cat. No. CS-0061371
  • Purity≥98%
  • MDL No.MFCD18449257

*For research and further manufacturing use only, not for direct human use.

2,3-Dichloro-5,6-dimethylpyrazine|CS-0061371

Structure of 32493-79-1

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General Information

  • CAS No. 32493-79-1
  • Cat. No. CS-0061371
  • Purity ≥98%
  • MDL No. MFCD18449257
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆Cl₂N₂
  • Molecular Weight 177.03
  • Synonym(s) Pyrazine, 2,​
  • SMILES CC1=NC(=C(Cl)N=C1C)Cl

Description

2,3-Dichloro-5,6-dimethylpyrazine features a rigid pyrazine core with chlorine substituents at the 2,3-positions and methyl groups at the 5,6-positions, imparting enhanced electron deficiency and steric shielding. This configuration enables stable coupling in transition-metal-catalyzed transformations and facilitates incorporation into functionalized heterocyclic architectures for materials science and medicinal chemistry applications.

Application

2,3-Dichloro-5,6-dimethylpyrazine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its electron-deficient pyrazine core enables selective nucleophilic substitution reactions, while the methyl groups provide steric and electronic modulation. The molecule exhibits good bench stability and facilitates efficient functionalization under mild conditions, making it valuable for constructing complex nitrogen-containing scaffolds in API development.

Synthesis

  • Route1
    • null|null
      100450-13-3
    • ~%
    • In-stock
      2,3-Dichloro-5,6-dimethylpyrazine|CS-0061371
      32493-79-1

    References

    • Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
  • Route2

    References

    • Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
  • Route3
    • 5,6-Dimethyl-1,4-dihydropyrazine-2,3-dione|CS-0582015
      32493-62-2
    • ~%
    • In-stock
      2,3-Dichloro-5,6-dimethylpyrazine|CS-0061371
      32493-79-1

    References

    • Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.40024
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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