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CS-W001157 4
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2-Chloro-6-methylpyrazine

  • CAS No. 38557-71-0

  • Cat. No. CS-W000350
  • Purity≥98%
  • MDL No.MFCD00055032

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-methylpyrazine|CS-W000350

Structure of 38557-71-0

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General Information

  • CAS No. 38557-71-0
  • Cat. No. CS-W000350
  • Purity ≥98%
  • MDL No. MFCD00055032
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight 128.56
  • Synonym(s) 6-Methyl-2-chloropyrazine; 2-Chloro-6-methylpyrazine
  • SMILES Cc1[c-]n[c-]c(n1)Cl

Description

2-Chloro-6-methylpyrazine is a heterocyclic compound featuring a pyrazine core substituted with chlorine at C2 and a methyl group at C6. This configuration imparts enhanced electron deficiency and improved stability under standard handling conditions, enabling its use in synthetic routes requiring robust, moisture-tolerant building blocks.

Application

2-Chloro-6-methylpyrazine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its electrophilic chlorine at C2 enables palladium-catalyzed cross-coupling reactions, while the methyl group at C6 offers a handle for further functionalization. The pyrazine core provides metabolic stability and favorable pharmacophore properties, facilitating integration into bioactive scaffolds. Bench-stable and readily purified by flash chromatography, it functions effectively in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.43842
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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