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CS-W001157 4
Total: USD 88.00

3-Bromopyridazine

  • CAS No. 88491-61-6

  • Cat. No. CS-W004020
  • Purity≥95%
  • MDL No.MFCD10688587

*For research and further manufacturing use only, not for direct human use.

3-Bromopyridazine|CS-W004020

Structure of 88491-61-6

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General Information

  • CAS No. 88491-61-6
  • Cat. No. CS-W004020
  • Purity ≥95%
  • MDL No. MFCD10688587
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrN₂
  • Molecular Weight None
  • Synonym(s) Pyridazine, 3-bromo- (9CI)
  • SMILES BrC1=CC=CN=N1

Description

3-Bromopyridazine is a heterocyclic building block featuring a bromine substituent at the 3-position of the pyridazine ring. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The bromine moiety offers high reactivity under palladium-catalyzed conditions, facilitating rapid access to diverse substituted derivatives.

Application

3-Bromopyridazine serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biaryl and heteroaryl scaffolds. Its bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings under standard conditions. The pyridazine core provides inherent stability and orthogonal functionality for further derivatization, making it valuable for medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Chemische Berichte, , vol. 81, p. 1,10

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Warning
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.2391
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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