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CS-W001157 4
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3-Bromo-6-fluoropyridazine

  • CAS No. 1353854-35-9

  • Cat. No. CS-0156745
  • Purity≥97%
  • MDL No.MFCD21100194

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-fluoropyridazine|CS-0156745

Structure of 1353854-35-9

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General Information

  • CAS No. 1353854-35-9
  • Cat. No. CS-0156745
  • Purity ≥97%
  • MDL No. MFCD21100194
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrFN₂
  • Molecular Weight 176.97
  • Synonym(s) None
  • SMILES C1=CC(=NN=C1Br)F

Description

3-Bromo-6-fluoropyridazine is a fluorinated heterocyclic building block featuring complementary halogen handles for cross-coupling reactions. The electron-deficient pyridazine core enables efficient palladium-catalyzed transformations, while the ortho-bromine and fluoro substituents offer distinct reactivity profiles. This compound exhibits enhanced stability under standard handling conditions and serves as a key intermediate in medicinal chemistry and agrochemical synthesis.

Application

3-Bromo-6-fluoropyridazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine substituent enhances metabolic stability and modulates electronic properties. This dual functionality supports efficient synthesis of substituted heterocycles relevant to pharmaceutical development. Its bench-stable crystalline form simplifies handling and purification in routine synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.3782
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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