5-Chloro-3-methylpyrazine-2-carbonitrile

Name: 5-Chloro-3-methylpyrazine-2-carbonitrile
Brand: ChemScene
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CAS No. 1260665-75-5
Cat. No. CS-0334682
Purity≥98%
MDL No.None

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5-Chloro-3-methylpyrazine-2-carbonitrile|CS-0334682

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General Information

CAS No. 1260665-75-5
Cat. No. CS-0334682
Purity ≥98%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClN₃
Molecular Weight 153.57
Synonym(s) None
SMILES CC1=NC(=CN=C1C#N)Cl

Description

5-Chloro-3-methylpyrazine-2-carbonitrile features a pyrazine core functionalized with chlorine, methyl, and nitrile groups, enabling direct integration into heterocyclic scaffolds. The electron-deficient ring facilitates nucleophilic substitution, while the nitrile group serves as a handle for downstream derivatization. This compound demonstrates stability under standard bench conditions and is compatible with common synthetic protocols in medicinal chemistry and materials science.

Application

5-Chloro-3-methylpyrazine-2-carbonitrile serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyrazine scaffolds. Its complementary electron-withdrawing nitrile and chloro groups facilitate palladium-catalyzed cross-coupling reactions, while the methyl substituent provides a handle for further functionalization. The compound exhibits good bench stability and is compatible with standard synthetic workflows, making it a practical choice for medicinal chemistry and process development applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 49.57
LogP 1.3101
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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5-Chloro-3-methylpyrazine-2-carbonitrile

CAS No. 1260665-75-5

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