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CS-W001157 4
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5-Bromo-2-fluoro-3-methylpyridine

  • CAS No. 29312-98-9

  • Cat. No. CS-D0944
  • Purity≥98%
  • MDL No.MFCD03095091

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-3-methylpyridine|CS-D0944

Structure of 29312-98-9

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General Information

  • CAS No. 29312-98-9
  • Cat. No. CS-D0944
  • Purity ≥98%
  • MDL No. MFCD03095091
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 5-Bromo-2-fluoro-3-picoline
  • SMILES CC1=CC(Br)=CN=C1F

Description

5-Bromo-2-fluoro-3-methylpyridine features a strategically positioned bromo and fluoro substituent on a methylated pyridine core, enabling selective cross-coupling and functionalization. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key intermediate in medicinal chemistry campaigns requiring regioselective transformations under standard conditions.

Application

5-Bromo-2-fluoro-3-methylpyridine serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-halogenated pyridine framework supports efficient C–H activation and Suzuki-Miyaura coupling, while the methyl group provides a site for directed metallation or oxidation. Bench-stable and compatible with standard reaction conditions, it facilitates the construction of complex heterocyclic scaffolds found in pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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