Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde

  • CAS No. 875781-15-0

  • Cat. No. CS-W019631
  • Purity≥98%
  • MDL No.MFCD09842440

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde|CS-W019631

Structure of 875781-15-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 875781-15-0
  • Cat. No. CS-W019631
  • Purity ≥98%
  • MDL No. MFCD09842440
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrFNO
  • Molecular Weight 204.00
  • Synonym(s) 5-Bromo-2-fluoronicotinaldehyde; 5-Bromo-2-fluoropyridine-3-carboxaldehyde; 5-bromo-2-fluoro-pyridine-3-carbaldehyde
  • SMILES O=CC1=CC(Br)=CN=C1F

Description

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde features a trifunctional pyridine core with strategically positioned bromo, fluoro, and aldehyde groups. This electron-deficient heterocycle enables direct coupling in cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The aldehyde functionality allows for facile derivatization under mild conditions, while the ortho-halogens support palladium-catalyzed transformations.

Application

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The aldehyde group facilitates nucleophilic additions and condensation reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by flash chromatography, it functions effectively in the construction of bioactive scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • US2008/293706 A1, ; Page/Page column 27; 85 ; US 20080293706 A1
  • Route2

    References

    • WO2006/15124 A2, ; Page/Page column 57-58 ; WO 2006/015124 A2
  • Route3
    • In-stock
      5-Bromo-2-fluoropyridine|CS-D0938
      766-11-0
    • null|null
      109-94-4
    • ~99%
    • In-stock
      5-Bromo-2-fluoro-3-pyridinecarboxaldehyde|CS-W019631
      875781-15-0

    References

    • WO2009/16460 A2, ; Page/Page column 52-53 ; WO 2009/016460 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.7957
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 875781-15-0 sigma875781-15-0 manufacturer875781-15-0 price875781-15-0 structure875781-15-0 SDSbuy 875781-15-0875781-15-0 supplier875781-15-0 uses875781-15-0 molecular weightprice of 875781-15-0875781-15-0 chemical name formula of 875781-15-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label