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CS-W001157 4
Total: USD 88.00

Piperidine-1-carbaldehyde

  • CAS No. 2591-86-8

  • Cat. No. CS-W016610
  • Purity≥98%
  • MDL No.MFCD00006483

*For research and further manufacturing use only, not for direct human use.

Piperidine-1-carbaldehyde|CS-W016610

Structure of 2591-86-8

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General Information

  • CAS No. 2591-86-8
  • Cat. No. CS-W016610
  • Purity ≥98%
  • MDL No. MFCD00006483
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) piperidine-N-carbaldehyde
  • SMILES O=CN1CCCCC1

Description

Bromoacetamido-PEG8-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Application

Piperidine-1-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient synthesis of nitrogen-containing heterocycles and bioactive molecules. Its aldehyde functionality facilitates reductive amination, imine formation, and coupling reactions with amines, hydrazines, and nucleophiles under mild conditions. The molecule exhibits good bench stability and is readily purified by distillation or chromatography, making it suitable for scale-up and multi-step synthetic sequences.

Synthesis

  • Route1
    • null|null
      110-89-4
    • null|null
      124-38-9
    • ~98%
    • In-stock
      Piperidine-1-carbaldehyde|CS-W016610
      2591-86-8

    References

    • US2014/18576 A1, ; Paragraph 0126-0136 ;
  • Route2
    • null|null
      110-89-4
    • null|null
      64-18-6
    • ~98%
    • In-stock
      Piperidine-1-carbaldehyde|CS-W016610
      2591-86-8

    References

    • Tetrahedron Letters, , vol. 54, # 16 p. 2077 - 2081
  • Route3
    • null|null
      110-89-4
    • null|null
      67-56-1
    • ~88%
    • In-stock
      Piperidine-1-carbaldehyde|CS-W016610
      2591-86-8

    References

    • Organic Letters, , vol. 15, # 7 p. 1776 - 1779

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   0.6287
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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