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CS-W001157 4
Total: USD 88.00

5-Bromo-2-fluoro-4-methylpyridine

  • CAS No. 864830-16-0

  • Cat. No. CS-W003663
  • Molecule weight190.01
  • Purity≥98%
  • MDL No.MFCD09839213

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-4-methylpyridine|CS-W003663

Structure of 864830-16-0

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General Information

  • CAS No. 864830-16-0
  • Cat. No. CS-W003663
  • Purity ≥98%
  • MDL No. MFCD09839213
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) Pyridine,5-bromo-2-fluoro-4-methyl-
  • SMILES CC1=CC(F)=NC=C1Br

Description

5-Bromo-2-fluoro-4-methylpyridine features a trifunctional pyridine core enabling direct incorporation into pharmaceutical scaffolds. The electron-deficient ring pairs with orthogonal halogen handles for late-stage diversification via cross-coupling. This bench-stable, moisture-tolerant reagent streamlines synthesis of kinase inhibitors and bioactive heterocycles under standard conditions.

Application

5-Bromo-2-fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The fluorine and bromine substituents offer orthogonal functionalization potential, while the methyl group enhances solubility and modulates electronic properties. This compound demonstrates excellent bench stability and facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Synthesis

  • Route1

    References

    • EP1726590 A1, ; Page/Page column 66 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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