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CS-W001157 4
Total: USD 88.00

4-Bromo-1,3-thiazole-2-carboxylic acid

  • CAS No. 88982-82-5

  • Cat. No. CS-W006047
  • Purity≥95%
  • MDL No.MFCD09701413

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1,3-thiazole-2-carboxylic acid|CS-W006047

Structure of 88982-82-5

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General Information

  • CAS No. 88982-82-5
  • Cat. No. CS-W006047
  • Purity ≥95%
  • MDL No. MFCD09701413
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrNO₂S
  • Molecular Weight 208.03
  • Synonym(s) 4-bromothiazole-2-carboxylic acid
  • SMILES O=C(C1=NC(Br)=CS1)O

Description

4-Bromo-1,3-thiazole-2-carboxylic acid features a brominated thiazole ring with a carboxylic acid group at the 2-position, offering a versatile scaffold for bioactive molecule synthesis. The electron-withdrawing bromine enhances reactivity in cross-coupling and functionalization reactions. This bench-stable compound integrates readily into pharmaceutical intermediates and agrochemical development workflows.

Application

4-Bromo-1,3-thiazole-2-carboxylic acid serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates amide formation, esterification, and derivatization. The molecule exhibits bench stability and good functional group tolerance, making it well-suited for modular synthesis of thiazole-based pharmacophores and API intermediates.

Synthesis

  • Route1
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      124-38-9
    • In-stock
      2,4-Dibromothiazole|CS-D1059
      4175-77-3
    • ~%
    • In-stock
      4-Bromo-1,3-thiazole-2-carboxylic acid|CS-W006047
      88982-82-5

    References

    • Journal of Fluorine Chemistry, , vol. 55, # 2 p. 173 - 178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6038
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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