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CS-W001157 4
Total: USD 88.00

3-Bromo-2-fluoro-4-methylpyridine

  • CAS No. 884495-46-9

  • Cat. No. CS-W003505
  • Purity≥98%
  • MDL No.MFCD08277289

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluoro-4-methylpyridine|CS-W003505

Structure of 884495-46-9

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General Information

  • CAS No. 884495-46-9
  • Cat. No. CS-W003505
  • Purity ≥98%
  • MDL No. MFCD08277289
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 3-Bromo-2-fluoro-4-picoline
  • SMILES Cc1ccnc(c1Br)F

Description

3-Bromo-2-fluoro-4-methylpyridine features a strategically positioned bromo and fluoro substituent on a methylated pyridine core, enabling selective cross-coupling reactions. The electron-deficient ring facilitates palladium-catalyzed transformations, while the methyl group enhances solubility and steric profile. This compound serves as a key intermediate in medicinal chemistry for constructing heterocyclic scaffolds under standard conditions.

Application

3-Bromo-2-fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The ortho-fluoro and meta-bromo substitution pattern provides orthogonal functionalization potential, while the methyl group enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard synthetic workflows facilitate efficient access to complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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