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6-Bromo-4-fluoro-1H-indazole

  • CAS No. 885520-23-0

  • Cat. No. CS-D0837
  • Purity≥96%
  • MDL No.MFCD07781444

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-fluoro-1H-indazole|CS-D0837

Structure of 885520-23-0

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General Information

  • CAS No. 885520-23-0
  • Cat. No. CS-D0837
  • Purity ≥96%
  • MDL No. MFCD07781444
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFN₂
  • Molecular Weight 215.02
  • Synonym(s) BROMOFLUOROINDAZOLE
  • SMILES FC1=CC(Br)=CC2=C1C=NN2

Description

6-Bromo-4-fluoro-1H-indazole features a fused bicyclic core with complementary halogen substituents enabling precise functionalization. The electron-deficient indazole scaffold supports efficient coupling reactions, while the bromo and fluoro groups offer orthogonal reactivity for modular synthesis in medicinal chemistry and materials development.

Application

6-Bromo-4-fluoro-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its compatible halogen substituents. The bromo and fluoro groups offer orthogonal reactivity for sequential functionalization, while the indazole core provides a rigid, bioactive scaffold. Its bench stability and ease of purification facilitate integration into multi-step syntheses for targeted compound libraries.

Synthesis

  • Route1

    References

    • WO2014/28591 A2, ;

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.4645
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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