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CS-W001157 4
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4-Bromo-6-fluoro-1H-indazole

  • CAS No. 885520-35-4

  • Cat. No. CS-0042112
  • Purity≥95%
  • MDL No.MFCD07781448

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-fluoro-1H-indazole|CS-0042112

Structure of 885520-35-4

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General Information

  • CAS No. 885520-35-4
  • Cat. No. CS-0042112
  • Purity ≥95%
  • MDL No. MFCD07781448
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFN₂
  • Molecular Weight 215.02
  • Synonym(s) None
  • SMILES FC1=CC2=C(C=NN2)C(Br)=C1

Description

4-Bromo-6-fluoro-1H-indazole is a heterocyclic building block featuring complementary halogen substituents at the 4- and 6-positions, enabling sequential cross-coupling reactions. The electron-deficient indazole core facilitates transition-metal-mediated functionalization, while the fluorine atom enhances metabolic stability and modulates electronic properties in bioactive molecule design.

Application

4-Bromo-6-fluoro-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its compatible halogen substituents. The fluorine and bromine groups offer orthogonal reactivity for sequential functionalization, while the indazole core provides a rigid, bioactive scaffold. Its bench stability and ease of purification support efficient synthesis workflows in API development and heterocyclic library construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.4645
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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