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CS-W001157 4
Total: USD 88.00

2-(5-Bromopyridin-2-yl)propan-2-ol

  • CAS No. 290307-40-3

  • Cat. No. CS-D0288
  • Purity≥96%
  • MDL No.MFCD11865230

*For research and further manufacturing use only, not for direct human use.

2-(5-Bromopyridin-2-yl)propan-2-ol|CS-D0288

Structure of 290307-40-3

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General Information

  • CAS No. 290307-40-3
  • Cat. No. CS-D0288
  • Purity ≥96%
  • MDL No. MFCD11865230
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrNO
  • Molecular Weight 216.08
  • Synonym(s) 5-Bromo-2-(1-hydroxy-1-methylethyl)pyridine
  • SMILES CC(O)(C1=NC=C(Br)C=C1)C

Description

A zwitterionic Good's Buffer

Application

2-(5-Bromopyridin-2-yl)propan-2-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromopyridine functionality. The tertiary alcohol group offers enhanced bench stability and facilitates purification, while the pyridine ring provides orthogonal reactivity for downstream modifications. Its structure supports efficient incorporation into bioactive scaffolds, particularly in kinase inhibitor and heterocyclic drug discovery programs.

Synthesis

  • Route1
    • In-stock
      2,5-Dibromopyridine|CS-W001991
      624-28-2
    • null|null
      67-64-1
    • ~88%
    • In-stock
      2-(5-Bromopyridin-2-yl)propan-2-ol|CS-D0288
      290307-40-3

    References

    • SIGNAL PHARMACEUTICALS, LLC; ELSNER, Jan; HARRIS, Roy, L.; LEE, Branden; MORTENSEN, Deborah; PACKARD, Garrick; PAPA, Patrick; PERRIN-NINKOVIC, Sophie; RIGGS, Jennifer; SANKAR, Sabita; SAPIENZA, John; SHEVLIN, Graziella; TEHRANI, Lida; XU, Weiming; ZHAO, Jingjing; PARNES, Jason; MADAKAMUTIL Loui; FULTZ Kimberly; NARLA, Rama K. Patent: WO2010/62571 A1, 2010 ; Location in patent: Page/Page column 94-95 ; WO 2010/062571 A1
  • Route2

    References

    • Pfizer Inc Patent: US2006/30714 A1, 2006 ; Location in patent: Page/Page column 7 ;
  • Route3

    References

    • Guay, Daniel; Girard, Mario; Hamel, Pierre; Laliberte, Sebastien; Friesen, Richard Patent: US2003/114478 A1, 2003 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.0715
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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