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CS-W001157 4
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2-(6-Bromopyridin-3-yl)propan-2-ol

  • CAS No. 477252-29-2

  • Cat. No. CS-0497104
  • Purity≥95%
  • MDL No.MFCD16988537

*For research and further manufacturing use only, not for direct human use.

2-(6-Bromopyridin-3-yl)propan-2-ol|CS-0497104

Structure of 477252-29-2

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General Information

  • CAS No. 477252-29-2
  • Cat. No. CS-0497104
  • Purity ≥95%
  • MDL No. MFCD16988537
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrNO
  • Molecular Weight 216.08
  • Synonym(s) 2-(6-bromo-3-pyridyl)propan-2-ol
  • SMILES CC(C)(O)C1=CC=C(Br)N=C1

Description

2-(6-Bromopyridin-3-yl)propan-2-ol features a brominated pyridine ring appended to a tertiary alcohol scaffold, delivering a bench-stable, moisture-tolerant building block for C–C coupling reactions. The sterically hindered hydroxyl group facilitates selective functionalization, while the electron-deficient pyridine moiety enables efficient transition-metal catalyzed transformations. This compound integrates seamlessly into complex molecular architectures under standard conditions.

Application

2-(6-Bromopyridin-3-yl)propan-2-ol serves as a versatile building block for C–C bond formation via palladium-catalyzed cross-coupling reactions. Its tertiary alcohol functionality enhances bench stability and simplifies purification, while the bromopyridine moiety enables reliable Suzuki, Stille, and Negishi couplings. This structure functions as a key intermediate in the synthesis of biologically active heterocycles and pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.0715
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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