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CS-W001157 4
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(4-(Benzyloxy)-3-methoxyphenyl)boronic acid

  • CAS No. 243990-53-6

  • Cat. No. CS-0174702
  • Molecule weight258.08
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-(Benzyloxy)-3-methoxyphenyl)boronic acid|CS-0174702

Structure of 243990-53-6

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General Information

  • CAS No. 243990-53-6
  • Cat. No. CS-0174702
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₅BO₄
  • Molecular Weight 258.08
  • Synonym(s) 4-Benzyloxy-3-methoxyphenylboronic acid
  • SMILES COC1=C(OCC2=CC=CC=C2)C=CC(B(O)O)=C1

Description

This boronic acid features a benzyloxy-substituted phenyl core with a methoxy group at the meta position, delivering enhanced stability and solubility in organic solvents. The pendant boronic acid moiety enables efficient Suzuki-Miyaura cross-coupling under mild conditions, facilitating rapid assembly of complex aryl architectures.

Application

(4-(Benzyloxy)-3-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The benzyloxy and methoxy groups provide orthogonal protection and electronic tuning, enhancing functional group tolerance. Its stability, ease of handling, and compatibility with diverse reaction partners make it ideal for medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1

    References

    • Synthetic Communications, , vol. 29, # 15 p. 2719 - 2730
  • Route2
    • null|null
      100-39-0
    • ~%
    • In-stock
      (4-(Benzyloxy)-3-methoxyphenyl)boronic acid|CS-0174702
      243990-53-6

    References

    • Tetrahedron Letters, , vol. 54, # 38 p. 5178 - 5180
  • Route3

    References

    • Tetrahedron Letters, , vol. 54, # 38 p. 5178 - 5180

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.92
  • LogP   0.954
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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