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CS-W001157 4
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1-(5-Bromopyridin-2-yl)ethan-1-ol

  • CAS No. 159533-68-3

  • Cat. No. CS-0169411
  • Purity≥96%
  • MDL No.MFCD07776421

*For research and further manufacturing use only, not for direct human use.

1-(5-Bromopyridin-2-yl)ethan-1-ol|CS-0169411

Structure of 159533-68-3

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General Information

  • CAS No. 159533-68-3
  • Cat. No. CS-0169411
  • Purity ≥96%
  • MDL No. MFCD07776421
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL
  • SMILES OC(C)C1=NC=C(Br)C=C1

Description

1-(5-Bromopyridin-2-yl)ethan-1-ol features a brominated pyridine ring linked to a benzylic alcohol, enabling direct functionalization in cross-coupling and derivatization workflows. The pendant hydroxyl group facilitates protection or oxidation to the corresponding aldehyde, while the electron-deficient heteroaryl moiety supports palladium-catalyzed transformations under standard conditions. This bench-stable reagent integrates readily into synthetic sequences requiring halogen-directed C–C or C–heteroatom bond formation.

Application

1-(5-Bromopyridin-2-yl)ethan-1-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a brominated pyridine moiety into target molecules. The primary alcohol functionality facilitates efficient derivatization via esterification, etherification, or coupling reactions. Its bench-stable nature and compatibility with standard cross-coupling protocols make it well-suited for late-stage functionalization and the construction of heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.8974
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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